References

Adams DD, Adams YJ, Knight JG, et al., 1984. A solution to the genetic and environmental puzzles of insulin-dependent diabetes mellitus. Lancet; i: 420-4.

Adams JF, 1958. Pregnancy and Addisonian pernicious anaemia. Scott Med J; 3: 21-5.

Adams PM, Fabncant JD, Legator MS, 1981. Cyclophosphamide. induced spermatogenic effects detected in the F1 generation by behavioural testing. Science; 211: 80-2.

Adler ID, 1982a. Germ-cell sensitivity in mammals. In: Sorsa M, Vainio H, eds. Mutagens in our environment. New York: Alan R Liss, 137-48.

Adler ID, 1982b. Male germ cell cytogenetics. In: Hsu TC, ed. Cyto genetic assays of environmental mutagens. Totowa NJ;

Allanheld, 249-76. Adler ID, 1982c. Mouse spermatogonia and spermatocyte sensitivity to chemical mutagens. Cytogenet Cell Genet; 33: 95 -100.

Adler ID, 1983a. Comparison of types of chemically induced genetic changes in mammals. MutatRes; 115: 293-321.

Adler ID, 1983b. Germ-cell sensitivity in mammals. MutatRes; 113: 221-327.

Alexander I, 1988. Chlamydia: one step forward or two backwards? Br MedJ; 297: 791.

Alink GM, Knize MG, Shen NH, Hesse SP, Felton JS, 1988. Mutagenicity of food pellets from human diets in Netherlands. Mutat Res; 206: 387-93.

Alvarez OM, Gilbreath RL, 1982. Thiamine influence on collagen 88during the granulation of skin wounds. J Surg Res; 32: 24-31

Ames BN, 1983. Which are the significant mutagens and antimutagens? MutatRes; 113: 223-4.

Ames BN, McCann J, Yamasaki E, 1975. Methods for detecting carcinogens and mutagens with the salmonella/mammalianmicrosome mutagenicity test. Mutat Res; 31: 347-64.

Ando 5, Rubens R, Rottiers R, 1984. Androgen plasma levels in male diabetics. J Endocrinol Invest, 7:21.

Arab L, Schellenberg B, Schlierf G, 1982. Nutrition and health; a survey of young men and women in Heidelberg. Ann Nutr Metab; 26 (suppl 1): 1-244.

Armstrong BK, Mann JI, Adelstein AM, Eskin F, 1975. Commodity consumption and ischaemic heart disease mortality with special reference to dietary practices. I Chron Dis; 28: 455-69.

Arnold DL, Boyes BG, 1989. The toxicological effects of saccharin in short-term genotoxicity assays. MutatRes; 221: 69-132.

Astaldi G, Strosseli E, Airo R, 1962. Ricerche citogenitiche nelle emopatie: osservazioni sui cromosomi dell92anaemia perniciosa non trattata. Boll Soc Ital Sper; 38: 111-4.

Auerbach C, Robson JM, 1946. Chemical production of mutations. Nature; 137: 302-4.

Aula P, 1965. Virus-associated chromosome breakage. A cytogenetic study of chickenpox, measles and mumps patients and of cell cultures infected with measles virus. Ann Acad Sci Fenn, A IV Biol; 89: I-78.

Badr FM, Badr RS, 1975. Induction of dominant lethal mutation in male mice by alcohol. Nature; 253: 133-6.

Badr FM, Rabouh SA, 1983. Effects of morphine sulphate on the germ cells of male mice. Terato genesis Carcinog Mutagen; 3:19 -26.

Badr FM, Raboub SA, Badr RS, 1979. Mutagenicity of methadone hydrochloride induced dominant lethal mutation and spermatocyte chromosomal aberrations in treated males. Mutat Res; 68: 235-49.

BakerR, Arlauskas A, Bonin A, Angus D, 1982. Detection of mutagenic activity in human urine following fried pork or bacon meals. Cancer Lett; 16: 8 1979.

Baker TG, 1982. Oogenesis and ovulation. In: Austin CR, Short RV, eds. Reproduction in Mammals Book 1: Germ cells and fertilization. Cambridge University Press, 17-45.

Bakke JL, Lawrence NL, Bennett J, Robinson 5, 1975. Endocrine syndromes produced by neonatal hyperthyroidism, hypothyroidism, or altered nutrition and effects seen in untreated progeny. In: Fisher DA, Burrow GN, eds. Perinatal Thyroid Physiology and Disease. New York: Raven Press, 107-13.

Ballard JL, Hoiroyde J, Tsang RC, Chan C, Sutherland JM, Knowles HC, 1984. High malformation rates and decreased mortality in infants of diabetic mothers managed after the first trimester of pregnancy 1956-1978. Am J Obstet Gynecol; 148: 1111-7.

Banduhn N, Obe C, 1985. Mutagenicity of methyl-2-benzimidazole carbamate, diethylstilbestrol and estradiol; structural chromosomal aberrations, sister-chromatid exchanges, C-mitoses polyploidies and micronuclci. MutatRes; 156: 199 -218.

Baraitser M, 1983. Relevance of a family history of seizures. Arch Dis Child; 58: 404-5.

Barale R, Zucconi D, Bertani R, Loprieno N, 1983. Vegetables inhibit, in vivo, the mutagenicity of nitrite combined with nitrosable compounds. MutatRes; 120: 145-50.

Barker DJP, Osmund C, 1986. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancer, i: 1077-81.

Barker DJP, Winter PD, Osmund C, Margetts B, Simmonds SJ, 1989. Weight in infancy and death from ischaemic heart disease. Lancet; ii: 577-80.

Barlow SM, Sullivan FM, 1982. Reproductive hazards of industrial chemicals. London: Academic Press.

Barnes B, Bradley SC, 1990. Planning for a healthy baby. London: Ebury Press.

Bamett AH, Eff C, Leslie RDG, Pyke DA, 1981. Diabetes in identical twins: a study of 200 pairs. Diabetologia; 20: 87 -93.

Barnett C, Chiang CWN, 1983. Effects of marihuana on testosterone in male subjects. I Theor Biol; 104: 685-92.

Bartak V, Josiflo M, Horackova M, 1-5. Juvenile diabetes and human sperm quality. IntJFertil; 20: 30-2.

Batzinger RP, Ou SYL, Bueding E, 1-8. Antimutagenic effects of 2-tert-butyl-4-hydroxyani sole and antimicrobial agents. Cancer Res; 38: 4478-85.

Beach RS, Gershwin ME, Hurley LS, 1982. Zinc, copper and manganese in immune function and expenmental oncogenesis. Nutr Cancer; 3: 172-91.

Beck L, Maier E, Schmidt E, Rohde J, 1978. Mutter-und Sduglingssterblichkeit. Stuttgart: Kohlhammer.

Becker K., Schoneich J, 1981. Effects of oestrogen on meiosis in female mice. Mutat Res; 85: 226.

Beek B, Jacky PB, Sutherland CR, 1983. DNA precursor deprivation-induced chromosomal damage. MutatRes; 113: 331.

Belko AZ, Obarzanek E, Kalkwarf HJ, et al., 1983. Effects of exercise on riboflavin re uirements of young women. Am] Clin Nutr; 37: 509-17.

Bell LT, Branstrator M, Roux C, Hurley LS, 1975. Chromosomal abnormalities in maternal and fetal tissues of magnesium and zinc-deficient rats. Teratology; 12: 221-6.

Bell TA, 1985. Chlamydia trachomatis, mycoplasma hominis and ureaplasma urealyticum of infants. Semin Perinatol; 9: 29-37.

Benda CE, 1949. Prenatal maternal factors in mongolism. JAMA; 139: 979-85.

Bender MA, Preston RI, 1982. Role of base damage in aberration formation. In: Natarajan AT, ed. Progress in mutation research; 4: 37-46. Amsterdam: Elsevier.

Bennett PH, Webner C, Miller M, 1979. Congenital anomalies in the diabetic and pre-diabetic pregnancy. In: Pregnancy metabolism, diabetes and the fetus. Amsterdam: Excerpta Medica, 207-18. (Ciba Foundation Symposium 63)

Beral V, Roman F, CoIwell L, 1984. Poor reproductive outcome in insulin-dependent diabetic women associated with later development of other endocrine disorders in the mothers. Lancere i: 4-7. van der Berg H, Schreurs WHP, Joosten GPA, 1978. Evaluation of the vitamin status in pregnancy. Inrernati Vitam NutrRes; 48: 12-21.

Berg K, ed. 1979. Genetic damage in man caused by environmental agents. New York: Academic Press.

Bergh T, Nilhuis SJ, Wide L, 1978. Serum prolactin and gonadotrophin levels before and after luteinizing hormone-releasing hormone in the investigation of amenorrhoea. Br J Obstet Gynaecol; 85: 945-6.

Bergstein NAM, 1979. Pregnancy metabolism, diabetes and the fetus. Amsterdam: Excerpta Medica, 275-6 (Ciba Foundation Symposium 63).

Bernhard P, 1962, Die Wirkung des Rauchens auf Frau und Mutter. Muench Med Wochenschr; 104: 1826-8.

Bhatnagar A, Rani R, Ghosh PK, 1984. Chromosome aberrations and sister-chromatid exchanges (SCEs) in peripheral blood lymphocytes of patients suffering from poliomyelitis. MutatRes; 141: 55-8.

Bjeldanes LF, Morris MM, Felton J, et al., 1982. Mutagens from the cooking of food; II survey by Ames/salmonella test of mutagen formation in the major protein-rich foods in the American diet. Food Chem & Toxicol; 20: 357-63.

Bjelke E, 1975. Dietary vitamin A and human lung cancer. IntJ Cancer; 15: 561-5.

Bjelke E, 1978. Dietary factors and the epidemiology of cancer of the stomach and large bowel. Aktuel Ernaehrungsmed Kim Prax: 2 (suppl): 10-7.

Bjerre B, Bjerre I, 1976. Significance of obstetric factors in prognosis of low birthweight children. Acta Paediatr Scand; 65: 544-6.

Blake CA, Scaramuzzi RJ, Norman RL, Kanematsu 5, Sawyer CH, 1972. Effect of nicotine on the proestrous ovulatory surge of LH in the rat. Endocrinology; 91: 1253-8.

Blank H, 1986. Papilloma viruses.. New York: John Wiley, 235. (Ciba Foundation Symposium 120).

Bleau C, Lemarbre J, Faucher C, Roberts KD, Chapdelaine A, 1984. Semen selenium and human fertility. Fertil Steril; 42: 890-4.

Boas F, 1941. The relation between physical and mental development. Science; 93: 339-42.

Bomsel-Helmreich 0, Gougeon A, Thebault A, et al., 1979. Healthy and atretic human follicles in the preovulatory phase. J Clin Endocrinol Metab; 48: 686-94.

Bonnar J, Redman CWG, Sheppard BL, 1975. Treatment of fetal growth and retardation in utero and dipyridamole. Eur J Obstet Gynaecol Reprod Biol; 5:123-34.

Bottura C, Coutinho V. 1967. The chromosome anomalies of the megaloblastic anaemias. Blut; 16: 193-9.

Boue JG, Boue A, 1-6. Chromosomal anomalies in early spontaneous abortions. In: Gropp A, Benirschke K, eds. Developmental biology and pathology. Heidelberg: Springer-Verlag, 193-208.

Boue JG, Boue A, Moorhead PS, Plotkin SA, 1964. Alt&ations chromosomiques induites par le virus de la rubeole dans les cellules embryonnaires diploides humaines cultive in vitro. CR Acad Sci; 259: 687-90.

Bout JG, Deluchat C, Nicolas H, Boue A, 1981 a. Prenatal losses of trisomy 21. In: Burgio GR et al., eds. Trisomy 2]. Heidelberg; Springer-Verlage.

Boue JG, Deluchat C, Nicolas H, Bout A, 1981b. Prenatal losses of trisomy 21. Hum Genet; (suppl. 2): 183-93.

Brandriff B, Gordon L, Ashworth L, et al., 1985. Chromosomes of human sperm: variability among normal individuals. Hum Genet; 70: 18-24.

Breart G, Rabarison Y, Plouin PF, Sureau C, Rumeau-Rouquette C, 1982. Risk of fetal growth retardation as a result of maternal hypertension. Dev Pharmacol Ther; 4 (suppl. 1): 116-23.

Brewen JG, Payne HS, 1979. X-ray stage sensitivity of mouse oocytes and its bearing on dose-response curves. Genetics; 91: 149-51.

Brewen JG, Payne HS, Jones KP, Preston RT, 1975. Studies on chemically induced dominant lethality; the cytogenetic basis of MMS-induced dominant lethality in post-meiotic male germ cells. Mutat Res; 33: 239-50.

Brewen JG, Payne HS, Preston RT, 1976. X-ray induced chromosome aberrations in mouse dictyate oocytes: I time and dose relationships. Mutat Res; 35: 111-20.

Bridges BA, 1987. Alcohol as a mutagenic agent. Mutat Res; 186: 173-6.

Bridges BA, Clemmesen J, Sugimura T, 1979. Cigarette smoking - does it carry a genetic risk^ MutatRes;65:71-81.

Briggs MH, 1973. Cigarette smoking and infertility in men. MedJAust; i: 616.

Brown GM, Garfinkel PE, Jeuniwic N, Moldofsky H, Stancer HC, 1977. Endocrine profiles in anorexia nervosa. In: Vigersky RA, ed. Anorexia nervosa. New York: Raven Press, 123-35.

Bruce WR, Varghese AJ, Wang S, Dion P, 1979. The endogenous production of nitroso compounds in the colon and cancer at that site. In: Miller EC et al., eds. Naturally occurring car- cinogens-mutagens and modulation of carcinogenesis. Baltimore University Park Press 221-8.

Brusick D, 1980. Principles of genetic toxicology. New York: Plenum Press.

Bryce-Smith D, 1985. Elemental nutrients and antinutrients in prenatal development. First Sym- posium on Preconception Care. Maidenhead: Wyeth, 10-3.

Bryce-Smith D, 1986. Environmental chemical influences on behaviour and mentation Chem Soc Rev; 15:93-123.

Bryce-Smith D, Deshpande R.R., Hughes T, Waldron HA, 1977. Lead and cadmium in still- births. Lawm; i:1159.

Buckton KE, 1983. Incidence and some consequences of X-chromosome abnormalities in live- bom infants. In: Sandberg AA, ed. Chromosome anomalies and their clinical manifestations New York: Alan Liss, 7-22.

Burger EJ, Tardiff RG, Scialli AR, Zenick H, 1989. Sperm measures and reproductive success New York; Alan Liss.

Burger GCE, Drummond JC, Sandstead HR, eds., 1948. Malnutrition and Starvation in Western Netherlands; September 1944 to July 1945. The Hague: General State Printing Office.

Burke BS, 1948. Nutritional needs in pregnancy in relation to nutritional intakes as shown in dietary histories. Obstet Gynecol Surv; 3: 716-27.

Burke BS, Harding VV, Stuart HC, 1943. Nutrition studies during pregnancy. J Pediatr; 23: 506-15.

Burke BS, Stevenson SS, Worcester J, Stuart HC, 1949. Nutrition studies during pregnancy: V Relation of maternal nutrition to condition of infant at birth: study of siblings. J Nutr; 38: 453-67.

Busch E, 1954. Versuche zur Beinflussung von Bullensperma durch Vitamin B12. Dissertation. Tierarztliche Hochschule, Hannover. Animal Breeding Abstracts; 25: 44, No. 147 1957.

Butcher RL, 1981. Experimentally induced gametopathies. In: Iffy L, Kaminetzky HA, eds. Principles and Practice of Obstetrics andPerinatology. New York: John Wiley, 339-49.

Butcher RL, Fugo NW, 1967. Overripeness and the mammalian ova: II Delayed ovulation and chromosomal anomalies. FertilSteril; 18: 297.

Butcher RL, Pope RS, 1979. Role of estrogen during prolonged estrous cycles of the rat on subsequent embryonic death or development Biol Reprod; 21: 491-5.

Butcher RL, 1976. Pre-ovulatory and post-ovulatory overripeness. Int J Gynaecol Obst; 14: 105-10.

Caan B, Horgen DM, Margen S, King JC, Jewell NP, 1987. Benefits associated with WIC supplemental feeding during the interpregnancy interval. Am J Clin Nutr; 45: 29-41.

Calabrese LH, Kirkendall DT, Floyd M, et al., 1983. Menstrual abnormalities, nutritional patterns and body composition in female classical ballet dancers. Physiol Sports Med; 11: 86-98.

Callard IP, Leathern JH, 1970. Pregnancy maintenance in protein deficient rats Acta Endocrinol (Copenh); 63: 544-559.

Canada, 1975. Nutrition Canada: Quebec. Ottawa: Department of Health and Welfare.

Carr DH, 1970. Chromosome abnormalities and spontaneous abortions. In: Jacobs PA, Price WH, Law P, eds. Human population cytogenetics. Edinburgh University Press, 103-18.

Cattanach BM, 1966a. Chemically induced mutations in mice. Mutat Res; 3: 346-53.

Cattanach BM, 1966b. Induction of paternal sex-chromosome losses and deletions and of auto- somal gene mutations by the treatment of mouse post-meiotic germ cells with triethylenemelamme lamme. Mutat Res; 4: 73-82.

Cattanach BM 1982. Induction of specific-locus mutations in female mice by triethyleneme- care: a manual for practice. New York: John Wiley, 1-10.

Chamberlain G, 1990. Preparing for pregnancy: a health primer for parents-to-be. London: Fontana.

Chamberlain G, Lumley J, eds. 1986. Prepregnancy care: a manual for practice. New York- John Wiley.

Chamberlain G, Philipp E, Hewlett B, Masters K, 1978. British Births 1970: vol 2 obstetric care London: Heinemann.

Chamberlain R, Chamberlain G, Hewlett B, Claireaux A, 1975. British Births 1970- vol 1 The first week of life. London: Heinemann.

Chamberlin J, Magenis RE, 1980. Parental origin of de novo chromosome rearrangements Hum (Genet; 53: 343-7.

Chandra RK, ed. 1988. Nutrition and immunology. New York- Alan Liss

Chang MW, Choi TK, Matsuo Y, Yoshii Z, 1984. Influence ofureaplasma urealyticum and my- coplasma homims on the human spermatozoal motility. Hiroshima J MedSci 33: 23-6

Charles D, Finland M, 1973. Obstetric and perinatal infections. Philadelphia: Le'a & Febieer

Cheek DB, Graystone J, Mehrizi A, 1966. The importance of muscle cell number in children with heart disease. Bull Johns Hopkins Hasp; 118-140-50

Chieri RA, Rivetta OM Foglia VG, 1969. Altered ovulation pattern in experimental diabetes. Fertil Steril; 20: 661-6.

Chu EHY, Generoso WM, 1983, eds. Mutation, cancer and malformations. New York: Plenum

Chung C, Mynonthopoulos WC, 1975. Effect of maternal diabetes on congenital malformations.

National Foundation March of Dimes, Original article series; 11- 23-8

Cicero TJ 1982 Alcohol-induced deficits in the hypothalamic-pituitary-luteinizing hormone axis in the male. Alcoholism (NY); 6: 207-15 v J 6

Cicero TJ, Meyer ER, Bell PD, 1979. Effect of ethanol on the hypothalamic-pituitary-luteinizing hormone axis and testicular steroidogenesis. I Pharmacol Exp Ther; 208: 2 10-15.

Clermont Y, Bustos-Obregon E, 1968. Re-examination of spermatogonial renewal in the rat by means of seminiferous tubules mounted in toto94. Am I Anat; 122: 237-48.

Clermont Y, Hermo L, 1975. Spermatogonial stem cells in the albino rat. Am I Anat; 142: 159- 76.

Commoner B, Vithayathil AJ, Polasa P, Nair S. Madyastha P, Cuca CC, 1978. Formation of mutagens in beef and beef extract during cooking. Science; 201: 913.

Coop IE, 1966. Effect of flushing on reproductive performance of ewes. I Agric Sci (Camb); 67: 30-23.

Courot M, 1982. Facteurs masculins de la fertilite apports et limites des 6tudes chez l92animal. In: Spira A, Jouannet P, eds. Lesfacteurs de lafertilitt humaine. Paris: INSERM, 45-56.

Cox BD, Lyon MF, 1-5. X-ray induced dominant lethal mutations in mature and immature oocytes of guinea-pigs and golden hamsters. Mutat Res; 28: 421-36.

Cruickshanks KJ, Dorman JS, Aarons J, et al., 1984. Pregnancy outcome in diabetics with other endocrine disorders. Lancet; i: 629-30.

Dansky LD, Andermann E, Andermann F, 1980. Marriage and fertility in epileptic patients. Epilepsia; 21: 261-71.

David C, 1982. Facteurs de variation des caract&istiques du sperme. In: Spira A, Jouannet P, eds. Lesfacteurs de lafertility humaine. Paris: INSERM; 57: 67.

Decker K, Hinselmann M, Clatzle D, 1-5. Anamie und Schwangerschaft. In: Brubacher G, Ritzel G, eds. Zur Ernahrungssituation der schweizerischen Bevolkerung. Bern.: Hans Huber; 221-32.

Dinsdale D, Williams RB, 1980. Ultrastructural changes in the sperm-tail of zinc-deficient rats. Journal of Comparative Pathology; 90: 559-66.

Dion PW, Brightsee ER, Smith CC, Bruce WR, 1982. The effect of dietary ascorbic acid and aipha-tocopherol on fecal mutagenicity. Mutat Res; 102: 27-37.

Distiller LA, Sagel J, Morley JE, Joffe BI, Seftel HC, 1975. Pituitary responsiveness to luteinizing hormone-releasing hormone in insulin-dependent diebetes mellitus. Diabetes; 24: 378-80.

Dizerega GS, Hodgen GD, 1981. Luteal phase dysfunction infertility: a sequel to aberrant folliculogenesis. Fertil Steril; 35: 489-99.

Dorfier R, Voigt A, 1966. Virus hepatitis and pregnancy, frequency and reciprocal influence. Muench Med Wochenschr; 108: 1042.

Doyle W, Crawford MA, Lawrence BM, Drury P. 1982. Dietary survey during pregnancy in a low socio-economic group. Hum Nutr: Appl Nutr; 36A: 95-106.

Doyle W, Crawford MA, Wynn AHA, Wynn SW, 1989a. Maternal magnesium intake and pregnancy outcome. Magnesium Res; 2: 205-10.

Doyle W, Crawford MA, Wynn AHA, Wynn SW, I 989b. Maternal nutrient intake and birth-weight. I Hum Nutr Diet; 2: 415-22.

Doyle W, Crawford MA, Wynn AHA, Wynn SW, 1990. The association of maternal diet and birth dimensions.JNutrMed; 1:9-16.

Dunn HG, Hughes CJ, Schulzer M, 1986. Physical growth. In: Dunn HG, ed. Sequelae of low birthweight: The Vancouver Study. Clinics in Developmental Medicine No. 95/96. Oxford: Blackwell, 35-53.

Eckhert CD, Hurley LS, 1-7. Reduced DNA synthesis in zinc deficiency: regional differences in embryonic rats. JNutr; 107: 855-61.

Edwards RG, Steptoe PC, 1975. Induction of follicular growth ovulation and luteinization in the human ovary. J Reprod Fertil; 22 (suppl): 12143.

Ehling UH, 1971. Comparison of radiation- and chemically- induced dominant lethal mutations in male mice. MutatRes; 11: 35-44.

Ehling UH, 1979. Induction of dominant lethal mutations in male mice by fosfestrol. Arch Toxicol; 42: 17 1977.

Ehling UH, Neuhauser-Klaus A, 1988. Induction of specific locus and dominant lethal mutations by cyclophosphamide and combined. cyclophosphamide radiation treatment in male mice. MutatRes; 199: 21-30.

Ejima Y, Sasaki MS, Kaneko A, Tanooka H, 1988. Types, rates, origin and expressivity of chromosome mutations involving 13q14 in retinoblastoma patients. Hum Genet; 79: 118-23.

Ek JI, 1959. Thyroid function in mothers of mongoloid infants. Acta Paediatr Scande 48: 33-42. Emerit I, Emerit J, Levy A, Kech M, 1979. Chromosomal breakage in Crohn92s disease: anticlastogenic effect of D-penicillamine and L cysteine. Hum Genet; 50: 51-7.

Emerit I, Emerit J, Tosoni-Pittoni A, Bousquet 0, Sarrazin A, 1972. Chromosome studies in patients with ulcerative colitis. Human genetik; 16: 313-22.

Emerit I, Feingold J, Camus J, Housset E, 1974. Etude chromosomique des maladies du collagene. Ann Genet (Paris); 17: 2514.

Emerit I, Marteau R, 1971. Chromosome studies in 14 patients with disseminated sclerosis. Human genetik; 13: 25-33.

EMIC-UK, The Environmental Mutagen Information Centre, United Kingdom Office, University College, Swansea.

Endo A, 1966. Teratogenesis in diabetic mice treated with alloxan prior to conception. Arch Environ Health; 12: 492-500.

Endo A, Ingalls TH, 1968. Chromosomal anomalies in embryos of diabetic mice. Arch Environ Health; 16: 316-25.

Epstein SS, Arnold E, Andrea J, Bass W, Bishop Y, 1972. Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicol AppI Pharmacol; 23: 288.

Epstein SS, Rohrborn G, 1970. Recommended procedures for testing genetic hazards from chemicals, based on the induction of dominant lethal mutations in mammals. Nature; 230: 459-60.

Esch MW, Easter RA, Bahr JM, 1981. Effect of riboflavine deficiency on estrous cyclicity in pigs. BiolReprod; 25: 659 -65.

European Environmental Mutagen Society, 1978. Mutagenicity screening: general principles and minimal criteria. MutatRes; 53: 361-7.

European Environmental Mutagen Society, 1983. Estimation of genetic risks and increased incidence of genetic disease due to environmental mutagens. Mutat Res; 115: 255-91.

Evered D, Clark 5, eds. 1986. Papillomaviruses. New York: John Wiley. (Ciba Foundation Symposium 120) Fairburn CU, McCulloch DK, Wu FC, 1982. The effects of diabetes on male sexual function. Clin Endocrinol Metab; 11: 749-67.

Fenech M, Morley AA, 1985. The effect of donor age on spontaneous and induced micronuclei. MutatRes; 148: 99-105.

Fialkow PJ, Thuline HC, Hecht F, Bryant J, 1971. Familial predisposition to thyroid disease in Down92s syndrome: controlled immunoclinical studies. Am J Hum Gener, 23: 67-86.

Field B, Kerr C, 1981. Season and interval for recurrence of neural tube defects. J Med Genet; 18: 484.

Finland M, 1973. Influenza complicating pregnancy. In: Charles D, Finland M, eds. Obstetric and Per inatal Infections. Philadelphia: Lee & Febiger, 35 5-98.

Fletcher AC, 1985. Reproductive hazards at work. Manchester: Equal Opportunities Commission.

Forbes AP, Engel E, 1963. The high incidence of diabetes mellitus in 41 patients with gonadal dysgenesis, and their close relatives. Metabolism; 12: 428-39.

Foresight: Association for the Promotion of Pre-Conceptual Care, 1985. Guidelines for future parents. Old Vicarage, Church Lane, Godalming, Surrey GU8 5PN.

Forteza BG, Baguena RC, 1963. Analisis citogenetico de un caso de anemia pernicioso antes y despues del tratamiento. Rev Gun Esp; 88: 251-54.

Fox BW, Jackson H, Craig AW, Glover TD, 1963. Effects of alkylating agents on spermatogenesis in the rabbit. J Reprod Fertil; 5:13-22.

Fratta ID, Sigg EB, Maiorana K, 1965. Teratogenic effect of thalidomide in rabbits, rats, hamsters and mice. Toxicol Appl Pharmacol; 7: 268-86.

Freed JJ, Schatz SA, 1969. Chromosomal aberrations in cultured cells deprived of single essential amino acids. Exp Cell Res; 55: 393-409.

Friedman JM, 1981. Genetic disease in the offspring of older fathers. Obstet Gynecol; 57: 745-9. Fries H, 1974. Secondary amenorrhoea and self-induced weight reduction and anorexia nervosa. Acta Psychiat Scand; 50 (suppl 248).

Frisch RE, 1977. Food intake, fatness and reproductive ability. In: Vigersky RA, ed. Anorexia nervosa. New York: Raven Press, 139-61.

Fuhrmann K, Reiher H, Semmler K, Fischer F, Fischer M, Glockner E, 1983. Prevention of congenital malformations in infants of insulin-dependent diabetic mothers. Diabetes Care; 6: 219-23.

Furuhjelm M, Jonson B, Lagergren CU, 1962. The quality of human semen in spontaneous abortion. IntJFertil; 7:17-21.

Gardner MJ, Snee MP, Hall AJ, Powell CA, Downs 5, Terrel JD, 1990. Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. Br Med J; 300: 423-9.

Gates AH, Donaldson CH, Levy MD, 1981. Oocyte aneuploidy screening using superovulating prepubertal mice: effect of methotrexate. Teratology; 24: 321-7.

Gavaler JS, Van Thiel DH, 1987. Reproductive consequences of alcohol abuse: males and females compared and contrasted. Mutat Res; 186: 269-77.

Gellis SS, HsiaY-YD, 1959. The infant of the diabetic mother. AmiDis Child; 97: 19741.

Gelpi AP, 1-0. Fatal hepatitis in Saudi Arabian women. Am I Gastroenterol; 53: 41.

Generoso WM, 1969. Chemical induction of dominant lethals in female mice. Genetics; 61: 461-70.Generoso WM, 1983. Dominant lethal mutations and heritable translocations in mice. In: Chu EHY, Generoso WM, eds. Mutation, cancer and malformations. New York: Plenum Press, 369-88.

Generoso WM, Cain KT, Cornett CC, Cacheiro NLA, 1984. DNA target sites associated with chemical inducation of dominant-lethal mutations and heritable translocations in mice. In:

Chopra VL, Joshi RP et al., eds. Genetics: new frontiers. Oxford University Press, 347-55.

Generoso WM, Rutledge JC, Cain KT, Hughes LA, Braden PW, 1987. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutat Res; 176: 269-74.

Generoso WM, Rutledge JC, Cain KT, Hughes LA, Downing DJ, 1988. Mutation-induced fetal anomalies and death following treatment of females within hours after mating. Mutat Res; 199: 175-81.

Gershenson SM, 1986. Viruses as environmental mutagenic factors. Mutat Res; 167: 203-13.

Ghosh R, Ghosh PK, 1983. Sister-chromatid exchanges in herpes simplex infection. MutatRes; 117: 303-8.

Giroud A, Lefebvres-Boisselot J, 1951. Anomalies provoquees chez le foetus en l92absence d92acide folique. Arch Fr Pediatr; 8: 648-56.

Giroud A, Ettori J, Boisselot J, 1949. Deficience en riboflavine chez Ia rate e Ia limite permittant Ia gestation. IntZ Vitaminforsch; 21: 26 1975.

Giroud A, Levy G, Lefrbvres-Boisselot J, 1950. Taux de la riboflavine chez le foetus de rat presentant des malformations dues a la deficience B2. Int Z Vitamin forsch; 22: 308-12.

Giroud A, Levy G, Lefebvres J, Dupuis R, Chute du taux de Ia riboflavine au stade ou se determinent les malformations embryonnaires. Int Z Vitaminforsch; 23: 490-4.

Giroud A, Tuchmann-Duplessis H, Mercier-Parot L, 1962. Observations sur les r6percussions teratogenes de la thalidomide chez Ia souris et le lapin. CR Soc Biol (Paris); 156: 765-8.

Glenting P, 1970. Etiology of congenital spastic cerebral palsy. Copenhagen: FADLs Forlag.

Goldstein 5, 1978. Human genetic disorders that feature premature onset and accelerated progression of biological aging. In: Schneider EL, ed. The genetics of ageing. New York: Plenum Press, 171-224.

Gontzea J, 1965. Die richtige Ernahrung der schwangeren und der stillenden Frau und ibre Bedeutung fur die Gesundheit von Mutter und Kind. Jena: Fischer Verlag.

Green S, Auletta A, Fabricant J, Kapp R, et al., 1985. Current status of bioassays in genetic toxicology 97 the dominant lethal assay. Mutat Res; 154: 49-67.

Greenwood M, 1928. "Laws" of mortality from the biological point of view. IHyg; 28: 267-94.

Gross SJ, Kosmetatos N, Grimes CT, Williams ML, 1978. Newborn head size and neurological status. Am J Dis Child; 132: 753-6. de Grouchy J, 1970. 21p-maternel en double exemplaire chez un trisomique 21. Ann Genet; 13: 52-5.

Gubler CJ, 1982. Thiamin: 20 years of progress. Ann NY Acad Sci; 378: 440.

Gunn SA, Gould TC, 1957. Hormone interrelationships affecting the selective uptake of 65Zn by the dorso-lateral prostate of the hypophysectomized rat. J Endacrinol; 16: 18-27.

Habibzadek N, Schorah CJ, Smithells RW, 1986. The effects of maternal folic acid and vitamin C nutrition in early pregnancy on reproductive performance in the guinea-pig. Brit J Nutr; 55: 23-35.

Hale F, 1933. Pigs born without eyeballs. JHered; 24: 105-6.

Halkka 0, Halkka L, 1969. Induction of chromosome aberrations in spermatogenesis by intracellular microbes. Chromosomes Today; 2: 61-9.

Hall M, Davidson RJL, 1968. Prophylactic folic acid in women with pernicious anaemia pregnant after periods of infertility. J. Clin Path; 21: 599-602.

Hamfelt A, Tuvemo T, 1972. Pyridoxal phosphate and folic acid concentration in blood and erythrocyte aspartate aminotransferase activity during pregnancy. Clin Chim Acta; 41: 287-98.

Hampar B, Ellison SA, 1961. Chromosomal aberrations induced by an animal virus. Nature; 192: 145-7.

Hansmann I, 1984. Aspects of nondisjunction. In: Obe 6, ed. Mutations in man. Heidelberg: Springer-Verlag, 147-55.

Hardy JB, Azarowicz EN, Mannini A, Medearis DN, Cooke RE, 1961. The effect of Asian influenza on the outcome of pregnancy, Baltimore 1957-58. Am J Public Health; 51: 1182-8.

Haresign W, Cole DJA, 1981. Recent Developments in ruminant nutrition. London: Butterworth. Harlap 5, Shiono PH, 1980. Alcohol, smoking and incidence of spontaneous abortions in the 1st and 2nd trimester. Lancet; ii: 173-76.

Harper MIK, 1982. Sperm and egg transport. In: Austin CR, Short RV, eds. Reproduction in mammals Book]: Germ cells and fertilization. Cambridge University Press: 102-27.

Harris JW, 1919. Influenza occurring in pregnant women. A statistical study of thirteen hundred and fifty cases. JAMA; 72: 978.

Hatanaka Y, Ueda K, 1981. High incidence of subclinical hypovitaminosis of B 1 among university students found by a field study in Ehime, Japan. MedJ Osaka Univ; 31: 83-14:11:51 23/07/0191.

Hayatsu H, Arminoto 5, Togawa K, Makita M, 1981a. Inhibitory effect of the ether extract of human feces on activities of mutagens: inhibition by oleic and linoleic acids. Mutat Res; 81: 287-93.

Hayatsu H, Inoue K, Ohta H, et al., 1981 b. Inhibition of the mutagenicity of cooked beef basic fraction by its acidic fraction. Mutat Res; 91: 437-42.

Hayatsu H, Hayatsu T, Ohara Y, 1985. Mutagenicity of human urine caused by ingestion of fried ground beef. Jpn J Cancer Res; 76: 445-8.

Hayatsu H, Arminoto 5, Negishi T, 1988. Dietary inhibitors of mutagenesis and carcinogenesis. Mutat Res; 202: 429-46.

Heap RB, Flint APF, 1984. Pregnancy. In: Austin CR, Short RV, eds. Reproduction in Mammals; Book 3 Hormonal control of reproduction. Cambridge University Press, 153-94.

Heath CW, 1966. Cytogenetic observations in vitamin B12 and folate deficiency. Blood; 27: 800-15.

Hecht F, Hecht BK, 1984. Fragile sites and chromosome breakpoints in constitutional rearrangements: II Spontaneous abortions, stillbirths and newborns. Clin Genet; 26: 174-77.

Heller CG, Clermont Y, 1964. Kinetics of the germinal epithelium in man. Recent Prog Horm Res; 20: 545-71.

Herrmann J, 1966. Der Einflul3 des Zeugungsalters auf die Mutationen zu Hamophilie A. Human genetik; 3:1-16.

Hertig AT, 1967. Human trophoblast: normal and abnormal. Am J Clin Pathol; 47: 249-70.

Hertig AT, Sheldon WH, 1943. Minimal criteria required to prove prima facie case of traumatic abortion or miscarriage. Ann Surg; 117: 595-606.

Hirvonen E, 1977. Etiology, clinical features and prognosis in secondary amenorrhoea. mt j Fertil; 22: 69-76.

Hjalmasson 0, Hagberg B, Hagberg G, 1988. Epidemiologic panorama of brain impairments and causative factors: Swedish experiences. In: Kubli F et al., eds. Perinatal events and brain damage in surviving children. Heidelberg: Springer-Verlag, 28-36.

Hongslo 1K, Christensen T, Brunborg G, Bjornstad C, Holme JA, 1988. Genotoxic effects of paracetamol in V79 Chinese hamster cells. Mutat Res; 204: 333-41.

Hook EB, 1982. Contribution of chromosome abnormalities to human morbidity and mortality. Cytogenet Cell Genet; 33: 101-6.

Hook, EB, Schreinmachers DM, Willey AM, Cross PK, 1984. Inherited structural cytogenetic abnormalities detected incidentally to fetuses diagnosed prenatally: frequency, parental-age associations, sex-ratio trends and comparisons with rates of mutants. Am J Hum Genet; 36: 422-43.

Howell WH, 1890. The life-history of the formed elements of the blood, especially the red corpuscles. J Morphol; 4: 57.

Howland BE, 1975. The influence of feed restriction and subsequent refeeding on gonadotrophin secretion and serum testosterone levels in male rats. I Rep rod Fertil; 44: 429-36.

Ho-Yen DO, J055 AWL, 1988. Toxoplasma and cytomegalovirus infections during pregnancy. Matern Child Health; 13: 225-7.

Hsu TC, Liang JC, Shirley LR, 1983. Aneuploidy induction by mitotic arrestants; effects of diazepam on diploid Chinese hamster cells. MutatRes; 122: 201-9. Huang HFS, Dyrenfurth I, Hembree WC, 1983. Endocrine changes associated with germ cell loss during vitamin A-induced recovery of spermatogenesis. Endocrinology; 112: 1163-71. Huang HFS, Marshall CR, 1983. Failure of spermatid release under various vitamin A states - an indication of delayed spermiation. BiolReprod; 28: 1163-72.

Hugenholtz AP, Bruce WR, 1976. Induction and transmission of elevated levels of abnormally shaped murine sperm. Can J Genet Cytol; 18: 564.

Hurley LS, 1979. Nutritional deficiencies and excesses. In: Wilson JG, Fraser FC, eds. Handbook of teratology. New York: Plenum Press, 261-308.

Hurley LS, 1981. Teratogenic aspects of manganese, zinc and copper nutrition. Physiol Rev; 61: 249-95.

Hurley R, 1983. Virus infections in pregnancy and the puerperium. In: Waterson AP, ed. Recent advances in clinical virology. Edinburgh: Churchill Livingstone, 19-55.

Hutchinson HE, Ferguson-Smith MA, 1959. The significance of Howell-Jolly bodies in red cell precursors. J Clin Pathol; 12: 45 1973.

ICPEMC; International Commission for Protection against Environmental Mutagens and Carcinogens, 1979. Cigarette smoking - does it carry a genetic risk? MutatRes; 65: 71-81.

ICPEMC; International Commission for Protection against Environmental Mutagens and Carcinogens, 1983. Estimation of genetic risks and increased incidence of genetic disease due to environmental mutagens. MutatRes; 115: 255-91.

ICPEMC; International Commission for Protection against Environmental Mutagens and Carcinogens, 1986. Inhibitors of mutagenesis and their relevance to carcinogenesis: report by expert group on antimutagens and desmutagens. Mutat Res; 168: 47-68.

Iffy L, 1981. The concept of the aging ovum. In: Iffy L, Kaminetzky, HA eds. Principles and Practice of Obstetrics and Perinatology, New York: John Wiley, 323-37.

livanainen M, 1974. A study on the origins of mental retardation. London: Heinemann. (Clinics in Developmental Medicine 51)

Im MJC, Freshwater MF, Hoopes YE, 1975. Enzyme activities in granulation tissue; energy for collagen synthesis. J Surg Res; 20: 12 1975.

Ivanov B, L6onard A, Deknudt C, 1973. Blood storage and the rate of chromosome aberrations after in vivo exposure to ionizing radiations. Radiat Res; 55: 469-76. Itokawa Y, Sasagawa 5, Fujiwara M, 1973. Effects of thiamine on lipid metabolism in magnesium deficient rats. I Nutr Sci Vitaminol (Tokyo); 19: 15-21.

Itokawa Y, Tseng LF, Fujiwara M, 1974. Thiamine metabolism in magnesium-deficient rats. J Nutr Sci Vitaminol (Tokyo); 20: 249-55.

Jacky PB, Beek B, Sutherland CR, 1983. Fragile sites in chromosomes: possible model for the study of spontaneous chromosome breakage. Science; 220: 69-70.

Jagiello C, 1981. Reproduction in Down92s syndrome. In: de Ia Cruz FF, Gerald PS, eds. Trisomy 21 (Down92s syndrome). Baltimore: University Park Press, 15 1-62.

Janz D, Beck-Mannagetta C, Scheffner D, Scholz C, 1982. Epilepsy in children of epileptic parents. In: Janz D, et al., eds. Epilepsy, Pregnancy and the Child. New York: Raven Press, 527-534.

Jolly J, 1905. Sur la formation des globules rouges des mammiferes. CR Soc Bid (Paris); 57: 528-31.

Jones KL, Smith DW, Harvey MAS, Hall BD, Quan L, 1975. Old paternal age and fresh gene mutation: Data on additional disorders. I Pediatr, 86: 84-8.

Jongbloet PH, 1986. Prepregnancy care: background biological effects. In Chamberlain C, Lumley J, eds. Prepregnancy care: a manualfor practice. New York: John Wiley, 3 1-52.

Jouannet P, Ducot B, Soumah A, Spira A, Feneux D, Albert M, 1981. Les caracteristiques du sperme des hommes f&onds et inf&onds. In: Spira A, Jouannet P. eds. Lesfacteurs de lafertilitte humaine. Paris: INSERM, 73-89.

Juberg RC, Mowrey PN, 1983. Origin of nondisjunction in trisomy 21 syndrome. Am J Med Genet; 16: 111-6.

Kada 1, 1982. Mechanisms and genetic implications of environmental antimutagens. In: Sugimura T, Kondo 5, Takebe H, eds. Environmental mutagens and carcinogens. New York: Alan Liss, 355-9.

Kada T, Marita K, Inoue T, 1978. Antimutagenic action of vegetable factor(s) on the mutagenic principle of tryptophan pyrolysate. Mutat Res; 53: 351-3.

Kada T, Kaneko K, Matsuzaki 5, Matsuzaki T, Hara Y, 1985. A case of the green tea factor. MutatRee 150: 127-32.

Kalimo K, Teho P. Honkonen E, Grdnroos M, Halonen P, 1981. Chlamydia trachomatis and herpes simplex virus IgA antibodies in cervical secretions of patients with cervical atypia. Br J Obstet Gynaecol; 88: 1130-4.

Kalla NR, 1981. Effect of vitamin A deficient diet on the spermatogenesis and plasma testosterone. Acta Europe Fertil; 12: 249-253.

Kamiguchi Y, Funaki K, Mikamo K, 1979. Chromosomal anomalies caused by preovulatory overripeness of the primary oocyte. Proc Jpn Acad; 55 B: 398-402.

Kaminetzky HA, Langer A, Baker H, et al, 1973. The effect of nutrition in teenage pregnancy and the status of the neonate. Am] Obstet Gynecol; 115: 639-46.

Karp LE, 1980. Older fathers and genetic mutations. Am J Hum Genet; 7: 405-6. Katoh M, Cacheiro NLA, Comett CV, Cain KT, Rutledge JC, Generoso WM, 1989. Fetal anomalies produced subsequent to treatment of zygotes with ethylene oxide or ethyl methanesulfonate are not likely due to the usual genetic causes. Mutat Res; 210: 3374.

Kaufman MH, 1982. The chromosome complement of single-pronuclear haploid mouse embryos following activation by ethanol treatment. J Embryol Exp Morphol; 71: 139-54.

Kaufman MH, 1983. Ethanol-induced chromosomal abnormalities at conception. Nature; 302: 25840.

Kaufman MH, 1985. An hypothesis regarding the origin of aneuploidy in man: indirect evidence from an experimental model.] Med Genet; 22: 17 1978.

Kato H, Sandberg AA, 1977. Effects of herpes simplex virus on sister chromatid exchanges and chromosome abnormalities in human diploid fibroblasts. Exp Cell Res; 109: 423-7.

Kendall EJC, 1985. Acute respiratory infections in the population. JR Soc Med; 78: 282-90. Kibrick 5, 1973. Herpes Simplex. In: Charles D, Finland M, eds. Obstetric and perinatal infections. Philadephia: Lea & Febiger, 75-94.

Kinzey WG, Srebnik HH, 1963. Maintenance of pregnancy in protein-deficient rats with short-term injections of ovarian hormones. Proc Soc Exp Biol Med; 114: 158-60.

Kiossoglou KA, Mitus WJ, Dameshek W, 1965. Chromosomal aberrations in pernicious anemia. Study of three cases before and after therapy. Blood; 25: 662.

Kirk KM, Lyon MF, 1982. Induction of congenital anomalies in offspring of female mice exposed to varying doses of X-rays MutatRes; 106: 73-83.

Kirk KM. Lyon MF, 1984. Induction of congenital malformations in the offspring of male mice treated with X-rays at pre-meiotic and post-meiotic stages. Mutat Res; 125: 75-85.

Kline J, Shrout P, Stein Z, Susser M, Warburton D, 1980. Drinking during pregnancy and spontaneous abortion. Lancet; ii: 176-80.

Kline J, Stein ZA, Susser M, Warburton D, 1977. Smoking: a risk factor for spontaneous abortion. New Engl J Med; 2-: 7934.

Kline J, Levin B, Stein Z, Susser M, Warburton D, 1981. Epidemiologic detection of low dose effects on the developing fetus. Environ Health Perspec; 42: 119-26.

Knoll JH, Chudley AE, Gerrard JW, 1984. Fragile (X) X-linked mental retardation: H Frequency and replication pattern of fragile (X) (q28) in heterozyotes. Am J Hum Genet; 36: 640-5.

Knudsen I, 1986. ed. Genetic toxicology of the diet. New York: Alan Liss. (Progress in Clinical and Biological Research 206).

Knudsen I, Hansen EV, Meyer OA, Poulsen E, 1977. A proposed method for the simultaneous detection of germ cell mutations leading to fetal death and of malformations in mammals. Mutat Res; 48: 267-70.

Knuth VA, Hull MGR, Jacobs HS, 1977. Amenorrhoea and loss of weight. Br J Obstet Gynaecol; 84: 801-7. S, 1977. Amenorrhoea and loss of weight. Br J Obstet Gynaecol; 84: 801-7.

Kocisova J, Rossner P, Binkova B, Bavorova H, Sram RJ, 1988. Mutagenicity studies on paracetamol in human volunteers: I Cytogenetic analysis of peripheral lymphocytes and lipid peroxidation in plasmas. MutatRes; 209: 16 1975.

Kodama Y, 1982. Cytogenetic and dermatoglyphic studies on severely handicapped patients in an institution. Acta Med Okayama; 36: 383-97.

Koller 5, 1983. Risikofaktoren der Schwangerschaft. Heidelberg: Springer-Verlag.

Koe92aatsu H, Kakiiioe I. NiieiixxaT , eavexciexiT , Sxe~vae.I, \9%2. seaseA wpexm W\xee due to dietary restriction. Murat Res; 93: 439-46.

Konstantinova B, Bratanova N, 1969. Chromosomal aberrations in patients with ulcerohaemorrhagic colitis. Digestion; 2: 329-37.

Kram D, Schneider EL, 1987. Parental-age effects. Increased frequencies of genetically abnormal offspring. In: Schneider EL, ed. The genetics of aging. New York: Plenum Press, 27-49.

Kubler W, Moch KJ, 1975. Zur Deckung des Vitaminbedarfs in der Schwangerschaft. In: Brubacher G, Ritzel G, eds. Zur Erndhrungssituation der schweizerischen Bevolkerung. Vienna: Hans Huber, 233-41.

Kuhnlein HV, Kuhnlein V, Bell PA, 1983. The effect of short-term dietary modification on human fecal mutagenic activity. MutatRes; 113:1-12.

Kuhnlein HV, Levander QA, King JC, Sutherland B, Piskie L, 1981. Dietary selenium and fecal mutagenicity in young men. Fed Proc; 40: 903.

Kummet I, Moon TB, Meyskens FL, 1983. Vitamin A: Evidence for its preventive role in human cancer. Nutr Cancer, 5: 96-106.

Kundsin PB, Ampola M, Streeter 5, Neurath, P, 1971. Chromosomal aberrations induced by T strain mycoplasmas. J Med Genet; 8:181-7.

Kurvink K, Bloomfield CD, Cervenka J, 1978. Sister chromatid exchange in patients with viral disease. Exp Cell Res; 113: 450-3.

Lai CN, Butler MA, Matney TS, 1980. Antimutagenic activities of common vegetables and their chlorophyll content. Mutat Res; 77: 245-50.

Lamson SH, Hook EB, 1980. A simple function for maternal age-specific rates of Down syndrome in the 20-to-49 year age range and its biological implications. Am J Hum Genet; 32: 743-53.

Lang K, 1955. Listeria-Infection als mogliche Ursache frub erworbener Cerebralschaden. Z Kinderheilk; 76: 328.

Langman J, van Faassen F, 1955. Congenital defects in the rat embryo after partial thyroidectomy of the mother animal. Am J Ophthalmol; 40: 65-76.

Larson CA, Nyman GE, 1973. Differential fertility in schizophrenia. Acta Psychiatr Scand; 49:272-80.

Lawrie CA, Renwick AG, Sims J, 1985. The urinary excretion of bacterial amino acid metabolites by rats fed saccharin in the diet. Food Chem Toxicol; 23: 445-50.

Lecorcbe, B. 1885. Du diabete dans ses rapports avec Ia vie ut&ine, Ia menstruation et la grossesse. Annales de Gyn&ologie; 24: 257-73.

Liang JC, Hsu TC, Henny JE, 1983. Cytogenetic assays for mitotic poisons. Mutat Res; 113: 467-9.

Licznerski G, Lindsten J, 1972. Trisomy 21 in man due to maternal non-disjunction during the first meiotic division. Hereditas; 70: 153-4.

Lindeskog P, Overvik B, Nilsson L, Nord CE, Gustafsson JA, 1988. Influence of fried meat and fiber on cytochrome P-450 mediated activity and excretion of mutagens in rats. Mutat Res; 204: 553-63.

Lubs ML, 1981. Mutation rates in severe hemophilia A and Duchenne muscular dystrophy. In: Hook EB, Porter IH, eds. Population and biological aspects of human mutation. New York: Academic Press, 91-116.

Lutwak-Mann C, 1964. Observations on progeny of thalidomide-treated male rabbits. Br Med J; ii: 1090-1.

Lutwak-Mann C, Schmid K, Keberle H, 1967. Thalidomide in rabbit semen. Nature; 214: 1018- 20.

Lyon MF, 1981. Sensitivity of various germ-cell stages to environmental mutagens. Mutat Res; 87: 323-45.

Lyon MF, 1985. Measuring mutation in man. Nature; 318: 315-6.

Lyon MF, 1988. Experimental work on induced mutations. Phil Trans R Soc Lond; B 319: 341-51.

Lyon MF, Renshaw R, 1986. Induction of congenital malformations in the offspring of mutagen treated mice. In: Ramel C, Lambert B, Magnusson J, eds. Genetic Toxicology of Environmental Chemicals, Part B, Genetic Effects and Applied Mutagenesis. New York: Liss, 449-58.

Lyon MF, Renshaw R, 1988. Induction of congenital malformation in mice by parental irradiation: transmission to later generations. Mutat Res; 198: 277-83.

Lyon MF, Phillips RJS, Fisher G, 1979. Dose-response curves for radiation induced gene mutations in mouse oocytes and their interpretation. Mutat Res; 63: 161-773.

McKusick VA, 1988. Mendelian inheritance in Man. Baltimore: Johns Hopkins University Press. 8th Edition.

McLaren A, 1982. The embryo. In: Austin CR, Short RV, eds. Reproduction in mammals Book 2: Embryonic and fetal development. Cambridge University Press, 1-25.

McLean BK, Rubel A, Nikitovitch-Winer MB, 1977. The differential effects of exposure to tobacco smoke on the secretion of luteinizing hormone and prolactin in the proestrous rat. Endocrinology; 100: 1566-70.

Mandello C, Giorgi R, Nuzzo F, 1984. Chromosomal effects of methotrexate on cultured human lymphocytes. Mutat Res; 139: 67-70.

Mahon R, 1972. Consultations d92un couple avant une grossesse. In: Amiel C, Brettes P. BriardGuillemot ML et al., Perinatalitte. Paris: INSERM et Masson, 1975.

Maine D, McNamara R, 1985. Birth spacing and child survival. Columbia University, Center for Population and Family Health.

Mann I, Lutwak-Mann CL, 1981. Male Reproductive Function and Semen. Heidelberg: Springer-Verlag.

Martin EC, 1978. Birth intervals and development of nine-year-olds in Singapore. IPPE Medical Bulletin; 12: 1973.

Martin GM, Sprague CA, Epstein CJ, 1970. Replicative life span of cultivated human cells. Lab Invest; 23: 86-92.

Martin RH, Rademaker A, 1988. The relationship between sperm chromosomal abnormalities and sperm morphology in humans. Mutat Res; 207: 159-64.

Mason KE, 1933. Differences in testes injury and repair after vitamin A deficiency, vitamin E deficiency and inanition. Am J Anat; 52: 153-239.

Maternity Alliance, 1990. Getting fit for pregnancy and Think about a baby? A man92s guide to preconception health. 15 Britannia Street, London WC1X 9JP.

Mathur U, Datta SL, Mathur BBL, 1977. The effect of aminopterin induced folic acid deficiency on spermatogenesis. Fertil Steril; 28: 1356-60.

Mattei JF, Mattei MG, Ayme 5, Giraud F, 1982. Contribution of the male to zygotic anomalies. In: Spira A, Jouannet P, eds. Lesfacteurs de lafertilite humaine. Paris INSERM, 171-81.

Mau G, Netter P, 1974. Die Auswirkungen des vaterlichen Zigarettenkonsums auf die perinatale Sterblichkeit und die

Missbildungshaufigkeit. Dtsch Med Wochenschr; 99: 1113-8.

Meisner LF, Inhorn SL, 1972. Chemically induced chromosome changes in human cells. Acta Cytol; 16: 417.

Menzies RC, Crossen PE, Fitzgerald PH, Gunz FW, 1966. Cytogenetic and cytochemical studies on marrow cells in B12 and folate deficiency. Blood; 28: 581-94.

Menzinger G, Gallucca F, Andreani D, 1966. Klinefelter92 s syndrome and diabetes mellitus. Lancet; i: 747.

Mikamo K, 1982. Meiotic chromosomal radiosensitivity in primary oocytes of the Chinese hamster. Cytogenet Cell Genet; 33: 88-94.

Mikamo K, Hamaguchi H, 1975. Chromosomal disorder caused by preovulatory overripeness of oocytes. In: Blandau RJ, ed. Aging gametes - their biology and pathology. Basel: S. Karger, AG, 72-97.

Mikamo K, Kamiguchi Y, 1983. Primary incidences of spontaneous chromosomal anomalies and their origins and causal mechanisms in the Chinese hamster. Mutat Res; 108: 265-78.

Millar MJ, Elcoate PV, Mawson CA, 1957. Sex hormone control of the zinc content of the prostate. Can J Biochem Physiol; 35: 865-8.

Milunsky A, 1969. Glucose intolerance in the parents of children with Down92s syndrome. Amer JMentDefic; 74: 475 978.

Mitranond V. Sobhon P. Tosukhowong P. Chindaduangrat W, 1979. Cytological changes in the testes of vitamin-A-deficient rats. Acta Anat; 103: 159-68.

Montreal Diet Dispensary. Annual Reports, 2182 Lincoln Aye, Montreal, H3H IJE, Quebec, Canada.

Morita K, Hara M, Kada T, 1978. Studies on natural desmutagens; screening for vegetable and fruit factors active in inactivation of mutagenic pyrolysis products from amino acids. Agric Biol Chem; 42: 1235-8.

Morley D, Lovel H, 1986. My name is today. London: Macmillan for UNICEF.

Morrow DA, 1980a. Nutrition and fertility. Modern Veterinary Practice; 61: 499-503.

Morrow DA, 1980b. The role of nutrition in dairy cattle reproduction. In: Morrow DA, ed. Current Therapy in Theriogenology. Philadelphia: Saunders, 449-55.

Mortimer D, Leslie EE, Kelly RW, Templeton AA, I 982a. Morphological selection of human spermatozoa in vivo and in vitro. J Reprod Fertil; 64: 391-9.

Mortimer D, Templeton AA, Lenton EA, Coleman RA, 1982b. Semen analysis parameters of a population of suspected infertile men. In: Spira A, Jouannet P, eds. Lesfacteurs de laferti1ite humaine. Paris: INSERM, 91-5.

Moser HW, 1985. Biologic factors of development. In: Freeman, 3M, ed, Prenatal and perinatal factors associated with brain disorders. Washington DC: US Department of Health and Human Services; NIH Publication no 85-1149.

Mtiller-Tyl P, Riss P, Janisch H, Fischl F, Deutinger J, 1984. Physiology of the ovarian follicle. Arch Androl; 12: 149 -56.

Mulley JC, Sutherland GR, 1983. Protease inhibitor (P1) phenotype of individuals with chromosomal fragile sites. Ann Genet (Paris); 26: 143-6.

Muuioz G, Malave TB, 1979. Influence of dietary protein restriction on ovulation, fertilization rates and pre-implantation embryonic development in mice. I Exp Zool; 210: 253-8.

Murdoch fl, Walker BA, Hall JG, Abbey H, Smith KK, McKusick VA, 1970. Achondroplasia - a genetic and statistical survey. Ann Hum Genet; 33: 227-44.

Myers CR, 1938. An application of the control group method to the problem of the etiology of mongolism. Proc Amer Assoc Mental Defic; 62: 142.

Nagao T, 1987. Frequency of congenital defects and dominant lethals in the offspring of male mice treated with methylnitrosourea. Mutat Res; 177: 171-8.

Navarrete VN, Torres IH, Rivera IR, Shor VP, Garcia PM, 1967. Maternal carbohydrate disorder and congenital malformations. Diabetes; 16: 127-30.

Nelson KB, Deutschberger J, 1970. Head size at one year as a predicator of four-year IQ. Dev Med Child Neurol; 12: 487-95.

Nelson ME, Fisher EC, Catsos PD, Meredith CN, Turksoy RN, Evans WJ, 1986. Diet and hone status in amenorrheic runners. Am J Clin Nutr; 43: 910-6.

Nelson MM, Evans HM, 1949. Pteroylglutamic acid and reproduction in the rat. J Nutr; 38: 11 - 24.

Nelson MM, Evans HM, 1954. Maintenance of pregnancy in the absence of dietary protein with estrone and progesterone. Endocrinology; 55: 543-9.

Nelson MM, Evans HM, 1955. Relation of thiamine to reproduction in the rat. I Nutr; 55: 151 - 63.

Nelson MM, Lyons WR, Evans HM, 1951. Maintenance of pregnancy in pyridoxine-deficient rats when injected with estrone and progesterone. Endocrinology; 48: 726-32.

Nelson MM, Lyons WR, Evans HM, 1953. Comparison of ovarian and pituitary hormones for maintenance of pregnancy in pyridoxine-deficient rats. Endocrinology; 52: 585-9.

Newberne PM, Suphakam V, 1983. Nutrition and cancer; a review with emphasis on the role of vitamins C and E and selenium. Nutr Cancer; 5: 107-19.

Newmark HL, Mergens WJ, 1981. Blocking nitrosamine formation using ascorbic acid and alpha-tocopherol. In: Bruce WR, Correa P, Lipkin SR, Tannenbaum SR, Wilkins TD, eds. Gastrointestinal cancer, endogenous factors: Banbury Report 7. Cold Spring Harbor: Ban-bury, 285-304.

Nielsen J, 1966. Diabetes mellitus in parents with Klinefelter92s syndrome, Lancet; i: 1376.

Nielsen J, 1972a. Diabetes mellitus in patients with aneuploid chromosome aberrations and in their parents. Human genetik; 16: 165-70.

Nielsen J, 1972b. Immunological aberrations in patients with aneuploid chromosome abnormalities and in their parents. 8.Human genetilc, 16: 17 1976.

Nillius SJ, 1978. Epidemiology and endocrinology of weight-loss related amenorrhoea. In: Jacobs HS, Beard RW, eds. Advances in gynaecological endocrinology. London: Royal College of Obstetricians and Gynaecologists, 118-30.

Niswander KR, Gordon M, 1972. The women and their pregnancies. Washington: US Department of Health, Education & Welfare.

Niswander KR, Jackson EC, 1974. Physical characteristics of the gravida and their association with birthweight and perinatal death. Am I Obstet Gynecol; 119: 306-13.

Nomura T, 1975. Transmission of tumors and malformations to the next generation of mice subsequent to urethane treatment. Cancer Res; 35: 264-6.

Nomura 1, 1978. Changed urethane and radiation response of the mouse germ cell to tumour induction. In: Seven L, Knudsen AG, Franmen JF, eds. Tumours of Early Life in Man and Animals. Perugia: Grafica di Silvi, 873-91.

Nomura T, 1982. Parental exposure to X rays and chemicals induces heritable tumours and anomalies in mice. Nature; 296: 575-7.

Oakberg EF, 1979. Timing of oocyte maturation in the mouse and its relevance to radiation-induced cell killing and mutational sensitivity. Mutat Res; 59: 39-48.

Obe G, 1984. ed. Mutations in Man. Berlin Springer-Verlag.

Omori M, Chytil F, 1982. Mechanism of vitamin A action. JBiol Chem; 257: 14370-4.

Omran AR, Standley CC, 1976. Family frrmation patterns and health. Geneva: World Health Organization.

Ong T, Whong WZ, Stewart J, Brockman HE, 1986. Chlorophyllin: a potent antimutagen against environmental and dietary complex mixtures. Mutat Res; 173: Ill-5.

Ong T, Whong WZ, Stewart JD, Brockman HE, 1989. Comparative antimutagenicity of 5 compounds against 5 mutagenic complex mixtures in salmonella typhimurium strain TA 98. MutatRes; 222: 19-25.

OPCS: Office of Population Censuses and Surveys, 1983. Congenital malformation statistics, series MB3 no. 1. London: HMSO.

OPCS: Office of Population Censuses and Surveys, 1987. Infant and perinatal mortality 1985: birthweight, series 0H3 87/1. London: HMSO.

OPCS: Office of Population Censuses and Surveys, 1988. Congenital malformation statistics, series MB3 No 2.. London: HMSO.

Pandy VK, Parmeshwasan M, Soman SD, 1983. Concentrations of morphologically normal, motile spermatozoa: Mg, Ca and Zn in the semen of infertile men. Science Total Environment; 27: 49-52.

Papiemik E, 1978. La grossesse et les deficiences intellectuelles de l92enfant. Arch Fr Peed; 35: x97 xiv.

Parry Jones A, Murray W, 1958. The heights and weights of educationally subnormal children. Lancet; ii: 905.

Penrose LS, 1955. Parental age and mutation. Lancet; ii: 312.

Peterson RN, Freund M, 1975. The inhibition of the motility of human spermatozoa by various pharmacologic agents. Biol

Reprod; 13: 5524.

Phillips LS, Vassilopoulou-Sellin R, 1979. Nutritional regulation of somatomedin. Am I Clin Nutr; 32: 1082-96.

Pierson H, 1936. Experimentale Erzeugung von Uterusgechwiulsten bei Kaninchen durch Prolan. ZKrebsforschung; 45: 1-27.

Poland BJ, Miller JR, Harris M, Livingston J, 1981. Spontaneous abortion: a study of 1961 women and their conceptuses. Acta Obstet Gynecol Scand (Suppl. 102).

Pond WG, Wagner WC, Dunn JA, Walker EF, 1968. Reproduction and early postnatal growth of progeny in swine fed a protein-free diet during gestation. J Nutr; 94: 309-16.

Population Reports, 1983. Infertility and sexually transmitted disease. Series L No. 4, Baltimore: Johns Hopkins University Press.

Potier de Courcy G, 1966. Caractere globaux des metabo1ismes nucleique et prot&que chez le foetus de rat carence en acide pantotbenique. Arch Sci Physiol; 20: 43-63.

Potier de Courcy G, Bujoli J, 1981. Effects of diet with or without folic acid, and with and without methionine, on fetus development, folate stores and folic acid dependent enzyme activities in the rat. Biol Neonate; 39: 132-40.

Potier de Courcy G, Desmettre M, Miguet 5, 1970. Effets de la carence en riboflavine sur quelques elements min&aux des tissus foeto-maternels du rat. Arch Sci Physiol; 24: 183-95.

Potier de Courcy G, Terroine T, 1968. Consequences chez le rat de Ia carence en riboflavine sur Ia composition globale de certains tissus maternels et foetaux. Arch Sci Physiol; 22: 329-55.

Powers AC, Eisenbarth CS, 1985. Autoimmunity to islet cells in diabetes mellitus. Anna Rev Med; 36: 533-44.

Reidy JA, Zhou X, Chen AlL, 1983. Folic acid and chromosome breakage. Mutat Res; 122: 217-21.

Ritzel G, 1975. Evaluation von Ernahrungserhebungen im Rahmen der Basler Studie III. In: Brubacher C, Ritzel C, eds. Zur Erndhrungssituation der schweizerischen Bevolkerung. Bern: Verlag Hans Huber, 57-82.

Ross ML, Pike RL, 1956. The relationship of vitamin B6 to protein metabolism during pregnancy in the rat. J Nutr; 58: 251-67.

Rush D, 1986. Nutrition in the preparation for pregnancy. In: Chamberlain C, Lumley J, eds. Prepregnancy care: a manualfor practice. Chichester: John Wiley, 113-39.

Rush D, Alvir JM, Kenny DA, Johnson SS, Horwitz DG, 1988. Historical study of pregnancy outcomes. In: The National WIC Evaluation. Am J Clin Nutr; 48: 4 12-28.

Russell LB, 1956. Dominant lethals induced at a highly sensitive stage in mouse oogenesis. Anat Rec; 125: 647-8.

Russell LB, Russell WL, 1956. The sensitivity of different stages in nogensis to the radiation induction of dominant lethals and other changes in the mouse. In: Mitchell JS, Holmes BE, Smith CC, eds. Progress in Radiobiology. Edinburgh: Oliver & Boyd, 187-92.

Russell WL 1977. Mutation frequencies in female mice and the estimation of genetic hazards of radiation in women. Proc NatI Acad Sci; 74: 3523-7.

Russell WL, 1986. Positive genetic hazard predictions from short-term tests have proved false for results in mammalian spermatogonia with all environmental chemicals so far tested. In:

Ramel B, Lambert B, Magnusson J, eds. Genetic toxicology of environmental chemicals, part B: Genetic effects and applied mutagenesis. New York: Alan Liss, 67-74. (Progress in Clinical and Biological Research 209)

Russell WL, Hunsicker PR, 1983. Extreme sensitivity of one particular germ-cell stage in male mice to induction of specific-locus mutation by methylnitrosourea. Environ Mutagen; 3: 498.

Sanbom CF, Martin BJ, Wagner WW, 1982. Is athletic amenorrhoea specific to runners? Am J ObstetGynecol; 143: 859-61.

Sanger R, Tippett P, Gavin J, Teesdale P, Daniels CL, 1977. Xg groups and sex chromosome abnormalities in people of northern European ancestry. JMed Genet; 14: 210-1.

Sauberlich HE, Dowdy RP, Skala JH, 1977. Laboratory tests for the assessment of nutritional status. Cleveland: CRC Press.

Schempp W, Krone W, 1979. Deficiency of arginine and lysine causes increase in frequency of sister chromatid exchanges. Hum Genet: 51: 315-8.

Schmauch G, 1899. Ueber endoglobulare Korperchen in den Erythrocyten der Katze. Virchows Arch; 156: 201-44.

Schneider EL, 1978. Cytogenetics of aging. In: Schneider EL, ed. The genetics of aging. New York: Plenum Press, 27-49.

Schneider EL, 1980. Aneuploidy and ageing. In: Conference on Structural Pathology and the Biology ofAgeing. Freiburg: Zentrallaboratorium fUr Mutagenitatsprtifung, 221-34.

Schorah CJ, 1981. Vitamin C status in population groups. In: Counsell JN, Homig DH, eds. Vitamin C (ascorbic acid). London: Applied Science Publishers, 23-47.

Schroeder TM, 1982. Genetically determined chromosomal instability syndromes. Cytogenet Cell Genet; 33: 119-32.

Schroeder WT, Chao LY, Das DD, et al., 1987. Non-random loss of maternal chromosome 11 alleles in Wilm92s tumors. AmJHum Genet; 40: 413-20.

Schroeder-Kurth TM, Auerbach AD, Obe G, 1989, eds. Fanconi92s Anemia; clinical, cyto genetic and experimental aspects. Heidelberg: Springer-Verlag.

Scottish Health Service, 1977. Scottish Health Statistics, 1976. Edinburgh.

Seeliger HPR, 1961. Listeriosis. Basel: S. Karger A.G.

Sharma G, Polasa H, 1978. Cytogenetic effects of influenza virus infection on male germ cells of mice. Hum Genet; 45: 179-87.

Sharp AA, Witts U, 1962. Seminal vitamin B12 and sterility. Lancet; ii: 779.

Sherer GK, Jackson BB, Leroy EC, 1981. Chromosome breakage and sister chromatid exchange frequencies in scleroderma. Arthritis Rheum; 24: 1409-13.

Schimkin MB, Grady HG, 1940. Mammary carcinomas in mice following oral administration. Z Krebsforsch; 52: 158-9.

Sjodin P. Jilgerstad M, 1984. A balanced study of 14C labelled 3-H-imidazo [4, 5-f] quinolin-2-amines (IQ and MeIQ) in rats. Food Chem Toxicol; 22: 207-10.

Slater E, Hare EH, Price JS, 1971. Marriage and fertility of psychiatric patients compared with national data. Soc Biol; 18 (Suppl):560-573.

Smith CG, 1983. Reproductive toxicity; hypothalamic-pituitary mechanisms. Am I md Mcd; 4: 107-12.

Smith MD, 1962. Seminal vitamin B 12 and sterility. Lancer, ii: 934.

Smith TE, 1960. The Cocos-Keeling Islands: a demographic laboratory. Population Studies; 14: 94-7.

Smithells RW, Nevin NC, Seller MJ et al., 1983. Further experience of vitamin supplementation for prevention of neural tube defect recurrences. Lancet; i: 1027-3 1.

Soyka LF, Joffe JM, 1980. Male mediated drug effects on offspring. In: Schwarz RH, Yaffe SJ, eds. Drug and chemical risks to the fetus and newborn. New York: Alan Liss, 49-60.

Spatling L, 1987. Die Friihgeburt vor der 34sten Schwangerschaftswoche. Gyndkologe (Berlin); 20:4-13.

Spatling L, Spatling G, 1986. Magnesium supplementation in pregnancy: a double-blind study. Magnesium Bull; 8: 25 2 973.

Spatling U, Spatling G, 1988. Magnesium supplementation in pregnancy: a double-blind study. BrJ Obstet Gynaccol; 95: 120-5.

Sperling K, 1984. Frequency and origin of chromosome abnormalities in man. In: Obe G, ed. Mutations in Man. Heidelberg: Springer-Verlag, 128-46. van der Spuy ZM, Steer PJ, McCusker M, Steele SJ, Jacobs HS, 1988. Outcome of pregnancy in underweight women after spontaneous and induced ovulation. Br Med J; 296: 962-5.

Stavric B, 1984. Mutagenic food flavonoids. Fed Proc; 43: 2454-8.

Steel JM, Johnstone FD, Smith AF, Duncan UP, 1982. Five years92 experience of a 91prepregnancy94 clinic for insulin-dependent diabetics. Br Med J; 285: 353-6.

Stein Z, Susser M, Saenger G, Marolla F, 1975. Famine and human development. Oxford University Press.

Steinberg SE, Fonda 5, Campbell CL, Hillman RS, 1983. Cellular abnormalities in folate deficiency. BrJHaematol; 54: 605-12.

Stevenson AC, 1978. Effect of twelve folate analogues on human lymphocytes in vitro. In: Evans HJ, Lloyd DC, eds. Mutagen-induced chromosome damage in man. Edinburgh University Press. 227-3 8.

Stoll C, Roth MP, Bigel P, 1982. A reexamination of parental age effect on the occurrence of new mutations for achondroplasia. New York: Alan Liss, 4 19-26. (Progress in Clinical and Biological Research 104)

Stolzner W, 1919. Zur Aetiologie des Mongolismus. Munch Med Wochenschr; 66: 1493-4.

Sugimura T, 1985. Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process. MutatRes; 150: 33-41.

Sugimura T, Nagao M, 1982. The use of mutagenicity to evaluate carcinogenic hazards in our daily lives. In: Heddle IA, ed. Mutagenicity: new horizons in genetic toxiocology. New York, London: Academic Press, 73-88.

Sumbtiloglu K, Bertan M, Fisek NH, 1976. In: Omran AR, Standley CC, eds. Family formation patterns and health. Geneva: World Health Organization, 191-9.

Sussman A, Leonard JM, 1980. Psoriasis, methotrexate, and oligospermia. Arch Dermatol: 116: 215-7.

Sveriges officiella statistik, 1979. Allmiin hiilso och sjukveird 1976. Stockholm.

Tagami 5, Sudo K, 1982. Influence on ovulation and ovulated ova in mice of different dietary protein levels and feeding periods. Jpn J Zootech Sci; 53: 266-71.

Takahara H, Cosentino MJ, Cockett ATK, 1982. Zinc therapy alone or in combination with vancocelectomy to improve the fertility potential of the male J Androl; 3: 37.

Tawn EJ, Cartmell CL, 1989. The effect of smoking on the frequencies of asymmetrical and symmetrical chromosome exchanges in human lymphocytes. MutatRes; 224: 151-6.

Templeton AC, 1970. Generalized herpes simplex in malnourished children. J Clin Pathol; 23: 24-30.

Terwel L, van der Hoeven JCM, 1985. Antimutagenic activity of some naturally occurring compounds towards cigarette-smoke condensate and benzo [a] pyrene in the salmonella/micro-some assay. MutatRes; 152: 1-4.

Thalbammer 0, 1967. Prdnatale Erkrankungen des Menschen. Stuttgart: Thieme Verlag.

Tharapel AT, Tharapel SA, Bannerman RM, 1985. Recurrent pregnancy losses and parental chromosome abnormalities: a review BrJ Obstet Gynaecol; 92: 899-914.

Thompson 5, Lopez B, Wong K-H, et al., 1982. A prospective study of chlamydia and mycoplasma infections during pregnancy. In: Mardh PA, Moller B, Paavonen J, eds. Chlamydia trachomitis in genital and related infections. ScandJlnfectDis (suppl 32); 155-8.

Thompson LH, Tucker JD, Stewart SA, et al., 1987. Genotoxicity of compounds from cooked beef in repair-deficient CHO cells versus salmonella mutagenicity Muta genesis; 2: 483-7.

Timmermans L, 1974. Influence of antibiotics on spermatogenesis. J Urol; 112: 348-9.

Togucida I, Ishizaki K, Sasaki MS, et al., 1989. Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma. Nature; 338: 156-8.

Tomaszewski L, Zmudzka B, Nadworny 1, 1963. Seminal vitamin B12 and sterility. Lancer ie 170.

Torkelson TR, Sadek SE, Rowe UK, et al., 1961. Toxicologic investigation of 1,2 dibromo-3-chloropropane. Toxicol AppI Pharmacol; 3: 545-9.

Toth A, Lesser ML, Brooks C, Labriola D, 1980. Subsequent pregnancies among 161 couples treated for T-mycoplasma genital-tract infection. New Eng J Med; 308: 505-7.

Trasler JM, Hales BF, Robaire B, 1985. Paternal cyclophosphamide treatment of rats causes fetal loss and malformations without affecting male fertility. Nature: 316: 144-6.

Tremolieres, I, 1977. Nutrition, physiologie, comportement alimentaire. Paris: Dunod.

Tsuboi T, Endo 5, 1977. Incidence of seizures and EEG abnormalities among offspring of epileptic patients. Hum Genet; 36: 173-89.

Tsuchida WS, Uchida JA, 1974. Chromosome aberrations in spermatocytes and oocytes of mice irradiated prenatally. Mutat Res; 22: 277-80.

Tunbridge WMG, Evered DC, Hall R, et al., 1977. The spectrnm of thyroid disease in a community: The Whickham survey. Clin Endocrinol (04); 7: 48 1-93.

Unglaub-Leisten I, Stickl H, Frick E, Angstwurm H, Ring 1, 1975. Chromosomenuntersuchuw gen an peripheren Lymphozyten bei Patienten mit multipler Sklerose. Dtsch Med Wochenschr; 100: 2028-34.

US Centers for Disease Control, 1989. Contribution of birth defects to infant mortality, US 1986. Morbidity & Mortality Weekly Report; 38: No. 37.

US Department of Labor Occupational Safety and Health Administration, 1978. Occupational exposure to lead: final standard. Federal Register; 43 No 220: 52952-53014.

US National Academy of Sciences, 1980. Recommended dietary allowances 9th ed. Washington DC.

US National Center for Health Statistics, 1972. A study of infant mortality from linked records. DHEW Publication No. (HMS) 72-1055, Rockville, Maryland.

US National Center for Health Statistics, 1978. Characteristics of Births, United States 1973-75 DHEW Publication No. (PHS) 78-1908, Rockville, Maryland.

US National Center for Health Statistics, 1979. Dietary Intake Source Data, United States 1971-74 DHEW Publication No. (PHS) 79-1221, Hyattsville, Maryland.

US National Center for Health Statistics, 1987. Prevalence of known diabetes among Black Americans. Advance Data No. 130 DHEW Pub. No. (PHS) 87-1250, Hyattsville, Maryland.

US National Research Council, 1982. Diet, nutrition, and cancer. Washington DC: National Academy Press.

US Surgeon-General, 1980. The health consequences of smoking for women. Washington DC:

US Department of Health and Human Services.

Vigersky RA, Loriaux DL, 1977. Anorexia nervosa as a model of hypothalamic dysfunction. In:

Vigersky RA, ed. Anorexia nervosa New York: Raven Press, 109-21.

Vogel F, 1984. Gene or point mutations. In Obe G, ed. Mutations in Man, Heidelberg: Springer-Verlag, 1019727.

Wais 5, Salvati E, 1966. Klinefelter92s syndrome and diabetes mellitus. Lancet; i: 747.

Warkany J, 1971. Congenital malfortnations. New York: Year Book Medical Publishers.

Warkany J, Schraffenberger E, 1944. Congenital malformations induced in rats by maternal nutritional deficiency. J Nutr, 27: 477-84.

Warren MP, 1977. Weight loss and responsiveness to LH-RH. In: Vigersky RA, ed. Anorexia nervosa. New York: Raven Press. 189-98.

Watanabe G, 1979. Environmental determinants of birth defects prevalence. Contributions to Epidemiology and Biostatisti cs; 1: 91-100. Basel: S Karger, AG.

Watson AA, 1962. Seminal vitamin B12 and sterility. Lancet; ii: 644.

Watteville H, Jiirgens R, Pfalz H, 1954. Einfluss von Vitaminmangel auf Fruchtbarkeit, Schwangerschaft und Nachkommen. Schweiz Med Wochenschr; 84: 875-82.

Wauben-Penris PJJ, van Buul-Offers SC, 1982. Meiotic disjunction in male Snell dwarf mice. J Hered; 73: 365-9.

Weitberg AB, 1989. Effect of nicotinic acid supplementation in vivo on oxygen radical-induced genetic damage in human lymphocytes. MutatRes; 216: 197-201.

Werbach MR, 1989. Nutritional influences on illness. Wellingborough: Thorson.

Whorton MD, Milby TH, 1980. Recovery of testicular function among DBCP workers, J Occup Med; 22: 177-9.

Wiesner PJ, Parra WC, 1982. Sexually transmitted diseases: meeting the 1990 objectives 97 a challenge for the 1980s. Public Health Rep; 97: 409-16.

Westom L, 1980. Incidence, prevalence, and trends of acute pelvic inflammatory disease and its consequences in industrialized countries. Am Obstet Gynecol; 121: 707-13.

Westrom L, Mlirdh PA, 1983. Chlamydial salpingitis. Br Med Bull; 39: 145-50.

Whincup PH, Cook DG, Shaper AG, 1989. Early influences on blood pressure; a study of children aged 5-7 years. Br Med]; 299: 587-91.

Wilkins IF, Kilgour RJ, 1982. Production responses in selenium supplemented sheep in northern New South Wales. Aust J Exp Agric Anim Husbandry; 22: 18-28.

Williams DL, Hagen AA, Runyan JW, 1971. Chromosome alterations produced in germ cells of dogs by progesterone. J Lab Clin Med; 77: 417-29.

Winter RM, 1987. Population genetics implications of the premutation hypothesis for the generation of the fragile-X mental retardation gene. Hum Genet; 75: 269-71.

Wolner-Hanssen P, Merdh PA, 1984. In vitro tests of the adherence of chiamydia trachomatis to human spermatozoa. Fertil Steril; 42: 102-7.

World Health Organization, 1981. World Health Statistics, Geneva.

Wynn AHA, Crawford MA, Doyle Wendy, Wynn SW, 1991. Nutrition of women in anticipation of pregnancy. Nutr Health; 7: 69-88.

Wynn M, Wynn A, 1979. Prevention of handicap and the health of women. London: Routledge.

Wynn M, Wynn A, 1981a. The importance of nutrition around the time of conception in the prevention of handicap. Hum Nutr: ApplNutr; 1:12-18.

Wynn M, Wynn A, 198 lb. The prevention of handicap of early pregnancy origin: some evidence for the value of good health before conception. London: Foundation for Education & Research in Childbearing.

Wynn M, Wynn A, 1981 c. Historical associations of congenital malformations. mt i Environ Stud; 71: 7-12.

Wynn M, Wynn A, 1982. Lead and Human Reproduction. London: Campaign for Lead-free Air. Wynn M, Wynn A, 1987. Nutrition before conception and the outcome of pregnancy. Nutr Health. 5: 31-43.

Wynn M, Wynn A, 1987. Preconception hazards of alcohol, smoking and cannabis: Symposium City Universiiy London. Maidenhead: Wyeth.

Wynn M, Wynn A, I 988a. Health around conception: the health of the mother. Postgraduate Doctor; 11: 305-16. Barker Publications, 539 London Road, Middlesex TW7 4DA.

Wynn M, Wynn A, 1988b. Magnesium and other nutrient deficiencies as possible causes of hypertension and low birthweight. Nutr Health. 6: 69-88.

Wynn M, Wynn A, 1989. Health around conception: health of the father. Postgraduate Doctor; 12: 592-606. Barker Publications, 539 London Road, Middlesex TW7 4DA.

Wyrobek AJ, 1982. Methods for evaluating the influence of chemicals on human male fertility. In: Spira A, Jouannet P, eds. Les facteurs de la fertilite humaine. Paris: INSERM, 295-310.

Wyrobek AJ, Bruce WR, 1975. Chemical induction of sperm abnormalities in mice. Proc Natl Acad Sci; 72: 4425-29.

Wyrobek AJ, Gordon AL, Burkhart JG, etal., 1983. An evaluation of human sperm as indicator of chemically induced alterations of spermatogenic function. MutatRes; 115: 73-148.

Yamamoto M, Endo A, Watanabe G, Ingalls TH, 1971. Chromosomal aneuploidies and polyploidies in embryos of diabetic mice. Arch Environ Health; 22: 468-75.

Yamamoto M, Ito T, Watanabe M, Watanabe G, 1982. Causes of chromosomal anomalies suggested by cytogenetic epidemiology of induced abortions. Hum Genet; 60: 360-4.

Yano K, 1979. Effect of vegetable juices and milk on alkylating activity of N-methyl-N-nitrosourea. I Agric Food Chem; 27: 456-8.

Yerushalmy J, Bierman JM, Kemp DH, Connor A, French FE, 1956. Longitudianal studies of pregnancy on the island of Kauai, territory of Hawaii. Am] Obstet Gynecol; 71: 80-96.

Zacharias JF, Jenkins JH, Marion IP, 1984. The incidence of neural tube defects in the fetus and neonate of insulin-dependent diabetic women. Am] Obstet Gynecol; 150: 797.

Zellers JE, Gautieri RF, 1977. Evaluation of teratogenic potential of codeine sulphate in CF97I mice. I Pharmacol Sci; 66: 1727-31.

Zuppinger K, Engel E, Forbes AP, Mantooth L, Claffey J, 1967. Klinefelter92s syndrome, a clinical and cytogenetic study in twenty-four cases. Acta Endocrinol (Copenh); 113: 5-48.